Bone regenerating effect of surface-functionalized titanium implants with sustained-release characteristics of strontium in ovariectomized rats
Identifieur interne : 000A19 ( Main/Exploration ); précédent : 000A18; suivant : 000A20Bone regenerating effect of surface-functionalized titanium implants with sustained-release characteristics of strontium in ovariectomized rats
Auteurs : Vincent Offermanns [Autriche] ; Ole Zoffmann Andersen [Danemark] ; Gregor Riede [Autriche] ; Inge Hald Andersen [Danemark] ; Klaus Pagh Almtoft [Danemark] ; S Ren S Rensen [Danemark] ; Michael Sillassen [Danemark] ; Christian Sloth Jeppesen [Danemark] ; Michael Rasse [Autriche] ; Morten Foss [Danemark] ; Frank Kloss [Autriche]Source :
- International Journal of Nanomedicine [ 1176-9114 ] ; 2016.
Abstract
Since strontium (Sr) is known for its anabolic and anticatabolic effect on bone, research has been focused on its potential impact on osseointegration. The objective of this study was to investigate the performance of nanotopographic implants with a Sr-functionalized titanium (Ti) coating (Ti–Sr–O) with respect to osseointegration in osteoporotic bone. The trial was designed to examine the effect of sustained-release characteristics of Sr in poor-quality bone. Three Ti–Sr–O groups, which differed from each other in coating thickness, Sr contents, and Sr release, were examined. These were prepared by a magnetron sputtering process and compared to uncoated grade 4 Ti. Composition, morphology, and mechanical stability of the coatings were analyzed, and Sr release data were gained from in vitro washout experiments. In vivo investigation was carried out in an osteoporotic rat model and analyzed histologically, 6 weeks and 12 weeks after implantation. Median values of bone-to-implant contact and new bone formation after 6 weeks were found to be 84.7% and 54.9% (best performing Sr group) as compared to 65.2% and 23.8% (grade 4 Ti reference), respectively. The 12-week observation period revealed 84.3% and 56.5% (best performing Sr group) and 81.3% and 39.4% (grade 4 Ti reference), respectively, for the same measurements. The increase in new bone formation was found to correlate with the amount of Sr released in vitro. The results indicate that sputtered nanostructured Ti–Sr–O coatings showed sustained release of Sr and accelerate osseointegration even in poor-quality bone, and thus, may have impact on practical applications for medical implants.
Url:
DOI: 10.2147/IJN.S101673
PubMed: 27313456
PubMed Central: 4892864
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bone regenerating effect of surface-functionalized titanium implants with sustained-release characteristics of strontium in ovariectomized rats</title><author><name sortKey="Offermanns, Vincent" sort="Offermanns, Vincent" uniqKey="Offermanns V" first="Vincent" last="Offermanns">Vincent Offermanns</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-11-2431">Department of Cranio-, Maxillofacial and Oral Surgery, Medical University Innsbruck, Innsbruck, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Cranio-, Maxillofacial and Oral Surgery, Medical University Innsbruck, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Andersen, Ole Zoffmann" sort="Andersen, Ole Zoffmann" uniqKey="Andersen O" first="Ole Zoffmann" last="Andersen">Ole Zoffmann Andersen</name><affiliation wicri:level="1"><nlm:aff 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uniqKey="Andersen I" first="Inge Hald" last="Andersen">Inge Hald Andersen</name><affiliation wicri:level="1"><nlm:aff id="af3-ijn-11-2431">Tribology Centre, Danish Technological Institute, Aarhus, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Tribology Centre, Danish Technological Institute, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Almtoft, Klaus Pagh" sort="Almtoft, Klaus Pagh" uniqKey="Almtoft K" first="Klaus Pagh" last="Almtoft">Klaus Pagh Almtoft</name><affiliation wicri:level="1"><nlm:aff id="af3-ijn-11-2431">Tribology Centre, Danish Technological Institute, Aarhus, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Tribology Centre, Danish Technological Institute, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="S Rensen, S Ren" sort="S Rensen, S Ren" uniqKey="S Rensen S" first="S Ren" last="S 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xml:lang="fr">Autriche</country><wicri:regionArea>Department of Cranio-, Maxillofacial and Oral Surgery, Medical University Innsbruck, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27313456</idno><idno type="pmc">4892864</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892864</idno><idno type="RBID">PMC:4892864</idno><idno type="doi">10.2147/IJN.S101673</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000648</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000648</idno><idno type="wicri:Area/Pmc/Curation">000648</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000648</idno><idno type="wicri:Area/Pmc/Checkpoint">000853</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000853</idno><idno 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xml:lang="fr">Autriche</country><wicri:regionArea>Department of Cranio-, Maxillofacial and Oral Surgery, Medical University Innsbruck, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Andersen, Ole Zoffmann" sort="Andersen, Ole Zoffmann" uniqKey="Andersen O" first="Ole Zoffmann" last="Andersen">Ole Zoffmann Andersen</name><affiliation wicri:level="1"><nlm:aff id="af2-ijn-11-2431">Interdisciplinary Nanoscience Center (iNANO), Faculty of Science and Technology, Aarhus University, Aarhus, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Interdisciplinary Nanoscience Center (iNANO), Faculty of Science and Technology, Aarhus University, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Riede, Gregor" sort="Riede, Gregor" uniqKey="Riede G" first="Gregor" last="Riede">Gregor Riede</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-11-2431">Department of Cranio-, Maxillofacial and Oral Surgery, Medical University Innsbruck, Innsbruck, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Cranio-, Maxillofacial and Oral Surgery, Medical University Innsbruck, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Andersen, Inge Hald" sort="Andersen, Inge Hald" uniqKey="Andersen I" first="Inge Hald" last="Andersen">Inge Hald Andersen</name><affiliation wicri:level="1"><nlm:aff id="af3-ijn-11-2431">Tribology Centre, Danish Technological Institute, Aarhus, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Tribology Centre, Danish Technological Institute, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Almtoft, Klaus Pagh" sort="Almtoft, Klaus Pagh" uniqKey="Almtoft K" first="Klaus Pagh" last="Almtoft">Klaus Pagh Almtoft</name><affiliation wicri:level="1"><nlm:aff id="af3-ijn-11-2431">Tribology Centre, Danish Technological Institute, Aarhus, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Tribology Centre, Danish Technological Institute, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="S Rensen, S Ren" sort="S Rensen, S Ren" uniqKey="S Rensen S" first="S Ren" last="S Rensen">S Ren S Rensen</name><affiliation wicri:level="1"><nlm:aff id="af3-ijn-11-2431">Tribology Centre, Danish Technological Institute, Aarhus, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Tribology Centre, Danish Technological Institute, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Sillassen, Michael" sort="Sillassen, Michael" uniqKey="Sillassen M" first="Michael" last="Sillassen">Michael Sillassen</name><affiliation wicri:level="1"><nlm:aff id="af2-ijn-11-2431">Interdisciplinary Nanoscience Center (iNANO), Faculty of Science and Technology, Aarhus University, Aarhus, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Interdisciplinary Nanoscience Center (iNANO), Faculty of Science and Technology, Aarhus University, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Jeppesen, Christian Sloth" sort="Jeppesen, Christian Sloth" uniqKey="Jeppesen C" first="Christian Sloth" last="Jeppesen">Christian Sloth Jeppesen</name><affiliation wicri:level="1"><nlm:aff id="af3-ijn-11-2431">Tribology Centre, Danish Technological Institute, Aarhus, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Tribology Centre, Danish Technological Institute, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Rasse, Michael" sort="Rasse, Michael" uniqKey="Rasse M" first="Michael" last="Rasse">Michael Rasse</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-11-2431">Department of Cranio-, Maxillofacial and Oral Surgery, Medical University Innsbruck, Innsbruck, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Cranio-, Maxillofacial and Oral Surgery, Medical University Innsbruck, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Foss, Morten" sort="Foss, Morten" uniqKey="Foss M" first="Morten" last="Foss">Morten Foss</name><affiliation wicri:level="1"><nlm:aff id="af2-ijn-11-2431">Interdisciplinary Nanoscience Center (iNANO), Faculty of Science and Technology, Aarhus University, Aarhus, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Interdisciplinary Nanoscience Center (iNANO), Faculty of Science and Technology, Aarhus University, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Kloss, Frank" sort="Kloss, Frank" uniqKey="Kloss F" first="Frank" last="Kloss">Frank Kloss</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-11-2431">Department of Cranio-, Maxillofacial and Oral Surgery, Medical University Innsbruck, Innsbruck, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Cranio-, Maxillofacial and Oral Surgery, Medical University Innsbruck, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Nanomedicine</title><idno type="ISSN">1176-9114</idno><idno type="eISSN">1178-2013</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Since strontium (Sr) is known for its anabolic and anticatabolic effect on bone, research has been focused on its potential impact on osseointegration. The objective of this study was to investigate the performance of nanotopographic implants with a Sr-functionalized titanium (Ti) coating (Ti–Sr–O) with respect to osseointegration in osteoporotic bone. The trial was designed to examine the effect of sustained-release characteristics of Sr in poor-quality bone. Three Ti–Sr–O groups, which differed from each other in coating thickness, Sr contents, and Sr release, were examined. These were prepared by a magnetron sputtering process and compared to uncoated grade 4 Ti. Composition, morphology, and mechanical stability of the coatings were analyzed, and Sr release data were gained from in vitro washout experiments. In vivo investigation was carried out in an osteoporotic rat model and analyzed histologically, 6 weeks and 12 weeks after implantation. Median values of bone-to-implant contact and new bone formation after 6 weeks were found to be 84.7% and 54.9% (best performing Sr group) as compared to 65.2% and 23.8% (grade 4 Ti reference), respectively. The 12-week observation period revealed 84.3% and 56.5% (best performing Sr group) and 81.3% and 39.4% (grade 4 Ti reference), respectively, for the same measurements. The increase in new bone formation was found to correlate with the amount of Sr released in vitro. The results indicate that sputtered nanostructured Ti–Sr–O coatings showed sustained release of Sr and accelerate osseointegration even in poor-quality bone, and thus, may have impact on practical applications for medical implants.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mulder, Je" uniqKey="Mulder J">JE Mulder</name></author><author><name sortKey="Kolatkar, Ns" uniqKey="Kolatkar N">NS Kolatkar</name></author><author><name sortKey="Leboff, Ms" uniqKey="Leboff M">MS LeBoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beppu, K" uniqKey="Beppu K">K Beppu</name></author><author><name sortKey="Kido, H" uniqKey="Kido H">H Kido</name></author><author><name sortKey="Watazu, A" uniqKey="Watazu A">A Watazu</name></author><author><name sortKey="Teraoka, K" uniqKey="Teraoka K">K Teraoka</name></author><author><name sortKey="Matsuura, M" uniqKey="Matsuura M">M 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Ht" uniqKey="Aro H">HT Aro</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Autriche</li><li>Danemark</li></country></list><tree><country name="Autriche"><noRegion><name sortKey="Offermanns, Vincent" sort="Offermanns, Vincent" uniqKey="Offermanns V" first="Vincent" last="Offermanns">Vincent Offermanns</name></noRegion><name sortKey="Kloss, Frank" sort="Kloss, Frank" uniqKey="Kloss F" first="Frank" last="Kloss">Frank Kloss</name><name sortKey="Rasse, Michael" sort="Rasse, Michael" uniqKey="Rasse M" first="Michael" last="Rasse">Michael Rasse</name><name sortKey="Riede, Gregor" sort="Riede, Gregor" uniqKey="Riede G" first="Gregor" last="Riede">Gregor Riede</name></country><country name="Danemark"><noRegion><name sortKey="Andersen, Ole Zoffmann" sort="Andersen, Ole Zoffmann" uniqKey="Andersen O" first="Ole Zoffmann" last="Andersen">Ole Zoffmann Andersen</name></noRegion><name sortKey="Almtoft, Klaus Pagh" sort="Almtoft, Klaus Pagh" uniqKey="Almtoft K" first="Klaus Pagh" last="Almtoft">Klaus Pagh Almtoft</name><name sortKey="Andersen, Inge Hald" sort="Andersen, Inge Hald" uniqKey="Andersen I" first="Inge Hald" last="Andersen">Inge Hald Andersen</name><name sortKey="Foss, Morten" sort="Foss, Morten" uniqKey="Foss M" first="Morten" last="Foss">Morten Foss</name><name sortKey="Jeppesen, Christian Sloth" sort="Jeppesen, Christian Sloth" uniqKey="Jeppesen C" first="Christian Sloth" last="Jeppesen">Christian Sloth Jeppesen</name><name sortKey="S Rensen, S Ren" sort="S Rensen, S Ren" uniqKey="S Rensen S" first="S Ren" last="S Rensen">S Ren S Rensen</name><name sortKey="Sillassen, Michael" sort="Sillassen, Michael" uniqKey="Sillassen M" first="Michael" last="Sillassen">Michael Sillassen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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